Frequently Asked Questions (FAQs) on erythropoiesis-or-blood-formation | HospitalKhoj

ERYTHROPOIESIS OR BLOOD FORMATION

ERYTHROPOIESIS OR BLOOD FORMATION

Ques. 1        Describe the stages of Erythropoiesis or how erythropiesis occurs? What factors are responsible for Erythropoleses? [discuss the role of anoxia (hypoxia) & vitamins in erythropoiesis].

Ans.             In the early embryo – Red – call formation takes place in the area vasculosa of the yolk-sac. This consists of a syncytium of branched cells. The angioblasts from plexuses. Fluid droplets appear gradually in these syncytial masses & run together. Thus a part is hollowed out to from network of capillaries at abut the 3rd week of intra-uterine life. The remains of syncytial masses persist as endothelial lining which in places divides to form masses of round cells. These cells are calls Megaloblasts. They start acquiring Hb and are know as Erythroblasts.

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They become free in blood-stream, and finally about the mid-foetal life lose their nuclei to become non-nucleated discs.

Mid-foetal life to about 1 month before birth – As foetal development proceeds, the endothelial lining of vascular channels of the liver and the spleen divides and forms nucleated red cells. In acute haemopoietic crisis they may resume this function even after birth.

After birth – Red-cell formation takes place in red bone marrow. Its vascular bed is a meshwork of small blood sinuses called sinusoids lined by thin endothelium. A large number of these intercommunicating sinusoids are normally collapsed & quite impermeable to blood. Others are widely dilated, but owing to the vessels which lead to from them being contricted, they are isolated from the general circulation. Regions of low oxygen tension are thus produced, which serve as stimuli to formation of red cells. It is these collapsed inter-sinusoidal capillaries of ‘Sabin’ where erythropoiesis occurs after birth. Plasma filters in from adjacent capillaries & sweeps into circulation the newly formed red cells. The collapsed capillaries open up as soon as normoblasts have lost their nuclei.

  1. In the final stage of maturation the nuclei break up into fragments and disappear, leaving young red cellsThe cells are larger in number and the diameter of a cell varies from 5.5 to 8.8 (mean diameter is 7.3). Shape may be circular or bi-concave, when it is viewed from side, it looks like a dumb-bell. Average thickness is 2.2. Average surface is 120 sq.

    Functions of R.B.C. : (i) It maintains ionic balance and acid – base balance. (ii) It help to maintain viscosity of blood. (iii) Various pigments are derived from haemoglobin after the disintegration of the red cells, e.g. bilirubin, biliverdin etc. (iv) It helps respiration by carrying O2 and CO2.

    Development of R.B.C. : Development process of R.B.C. is Reticulo-Endothelial Cells – Haemocytoblast – Pro-erythroblast – Early normoblast – Late normoblast – Reticulocyte – Erythrocyte.

    Normal total count of R.B.C. : (i) In infants: 6 to 7 million/cu. mm. (ii) In adult male : 5 to 6 million / cu.mm. (iii) In adult female : 4 to 5 million / cu. mm. (iv) In foetus : 7 to 8 million / cu.mm.

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Comments

0 # Aarush 2017-08-29
Hello, plz tell me what are venereal diseases, can you plz suggest some good gynecologist in Guwahati ?
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0 # Dr. Pooja 2017-08-30
veneral diseases are those which can be spread through sexual contact, The spreading agents can bacteria ,viruses etc, The examples are syphilis and gonorrhoea can be can spread by sexual contact, you can also find list of Gynecologist in Guwahati.
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0 # Priyansh 2017-08-22
Hii, I am from Sharanpur, can you plz tell me What is the mode of infection in syphilis ?
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0 # Dr. Pooja 2017-08-23
90 percent cases in syphilis are transmitted through unsafe sexual contacts, Mothers can also pass infection through breast milk, you can also consult with good Gynecologist in Sharanpur .
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0 # Harikiran 2017-08-22
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in Bhor ?
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0 # Dr. Naresh 2017-08-23
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in Bhor
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0 # Himmat 2017-08-15
Hello, plz let me know What is menarche, I want to consult with gynec in Morena, plz suggest ?
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0 # Dr. Naresh 2017-08-16
the process of starting of the menstrual cycle in females is called menarche, plz find good Gynecologist in Morena.
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0 # Rohan 2017-08-08
Hello, plz let me know What is menarche, I want to consult with gynec in Giridih, plz suggest ?
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0 # Dr. Naresh 2017-08-09
the process of starting of the menstrual cycle in females is called menarche, plz find good Gynecologist in Giridih.
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0 # Himmat 2017-08-08
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Mahaboobnagar ?
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0 # Dr. Naresh 2017-08-09
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Mahaboobnagar
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0 # Nishith 2017-08-01
Hii, can you plz tell me,What changes can occur in skin in syphilis patient, also suggest good obstertrician in Amreli ?
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0 # Dr. Pooja 2017-08-02
Rashes can occur on the skin in the near areas,rashes can be discrete and also symmetrical in nature, Rashes can also be pustular, you can consult with Obstetrician in Amreli.
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0 # Tushar 2017-07-25
Can gonorrhoea be caused by the infected towels, also provide the list of good gynecologist in Solan?
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0 # Dr. Pooja 2017-07-26
Gonorrhoea can be transmitted by the infected towels, handkerchiefs of the infected person, But most cases are due to sexual contacts, find here list of good Gynecologist in Solan.
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0 # Lakshay Older than three months
Hii, I am from Rae Bareli, Please tell that can moisture be responsible for infections ?
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0 # Dr. Naresh Older than three months
Hello, good to see that you are from Rae Bareli, yes,that is why u must keep your genital organs clean and dry because moisture can favour infections.
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