Frequently Asked Questions (FAQs) on erythropoiesis-or-blood-formation | HospitalKhoj

ERYTHROPOIESIS OR BLOOD FORMATION

ERYTHROPOIESIS OR BLOOD FORMATION

Ques. 1        Describe the stages of Erythropoiesis or how erythropiesis occurs? What factors are responsible for Erythropoleses? [discuss the role of anoxia (hypoxia) & vitamins in erythropoiesis].

Ans.             In the early embryo – Red – call formation takes place in the area vasculosa of the yolk-sac. This consists of a syncytium of branched cells. The angioblasts from plexuses. Fluid droplets appear gradually in these syncytial masses & run together. Thus a part is hollowed out to from network of capillaries at abut the 3rd week of intra-uterine life. The remains of syncytial masses persist as endothelial lining which in places divides to form masses of round cells. These cells are calls Megaloblasts. They start acquiring Hb and are know as Erythroblasts.

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They become free in blood-stream, and finally about the mid-foetal life lose their nuclei to become non-nucleated discs.

Mid-foetal life to about 1 month before birth – As foetal development proceeds, the endothelial lining of vascular channels of the liver and the spleen divides and forms nucleated red cells. In acute haemopoietic crisis they may resume this function even after birth.

After birth – Red-cell formation takes place in red bone marrow. Its vascular bed is a meshwork of small blood sinuses called sinusoids lined by thin endothelium. A large number of these intercommunicating sinusoids are normally collapsed & quite impermeable to blood. Others are widely dilated, but owing to the vessels which lead to from them being contricted, they are isolated from the general circulation. Regions of low oxygen tension are thus produced, which serve as stimuli to formation of red cells. It is these collapsed inter-sinusoidal capillaries of ‘Sabin’ where erythropoiesis occurs after birth. Plasma filters in from adjacent capillaries & sweeps into circulation the newly formed red cells. The collapsed capillaries open up as soon as normoblasts have lost their nuclei.

  1. In the final stage of maturation the nuclei break up into fragments and disappear, leaving young red cellsThe cells are larger in number and the diameter of a cell varies from 5.5 to 8.8 (mean diameter is 7.3). Shape may be circular or bi-concave, when it is viewed from side, it looks like a dumb-bell. Average thickness is 2.2. Average surface is 120 sq.

    Functions of R.B.C. : (i) It maintains ionic balance and acid – base balance. (ii) It help to maintain viscosity of blood. (iii) Various pigments are derived from haemoglobin after the disintegration of the red cells, e.g. bilirubin, biliverdin etc. (iv) It helps respiration by carrying O2 and CO2.

    Development of R.B.C. : Development process of R.B.C. is Reticulo-Endothelial Cells – Haemocytoblast – Pro-erythroblast – Early normoblast – Late normoblast – Reticulocyte – Erythrocyte.

    Normal total count of R.B.C. : (i) In infants: 6 to 7 million/cu. mm. (ii) In adult male : 5 to 6 million / cu.mm. (iii) In adult female : 4 to 5 million / cu. mm. (iv) In foetus : 7 to 8 million / cu.mm.

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Comments

0 # Vaibhav 2017-11-28
Hii, I am from Nayagarh, I want to know can cigerrete sharing can lead to syphilis ?
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0 # Dr. Naresh 2017-11-29
yes,sharing cigerette,drinking cups,common spoons etc can also lead to syphilis, Generally whenever the fluid of a person who has syphilis is shared,the infection can occur, you should also consult with good Gynecologist in Nayagarh
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0 # Harikiran 2017-10-24
Hello I am from Solapur, My neighbour has been feeling redness and burning in urethral organs, can it be a disease, should she visit gynec?
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0 # Dr. Pooja 2017-10-25
It can be a simple infection also and a disease also, If after the examination, the presence of gram negative bacteria is seen ,gonorrhoea infection can be thought of, she should visit good women's specialist- find list of Gynecologist in Solapur
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0 # Vivaan 2017-10-10
Hii, can you plz tell me,What changes can occur in skin in syphilis patient, also suggest good obstertrician in Ratnagiri ?
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0 # Dr. Naresh 2017-10-11
Rashes can occur on the skin in the near areas,rashes can be discrete and also symmetrical in nature, Rashes can also be pustular, you can consult with Obstetrician in Ratnagiri.
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0 # Himmat 2017-10-03
Hello, plz let me know What is menarche, I want to consult with gynec in Kottayam, plz suggest ?
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0 # Dr. Pooja 2017-10-04
the process of starting of the menstrual cycle in females is called menarche, plz find good Gynecologist in Kottayam.
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0 # Harikiran 2017-10-03
Hii, I am from Sitamarhi, plz let me know What is gonorrhoea ?
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0 # Dr. Pooja 2017-10-04
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Sitamarhi, find list of Gynecologist in Sitamarhi
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0 # Aayush 2017-09-19
Hello, plz let me know What is menarche, I want to consult with gynec in Tikamgarh, plz suggest ?
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0 # Dr. Naresh 2017-09-20
the process of starting of the menstrual cycle in females is called menarche, plz find good Gynecologist in Tikamgarh.
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0 # Harikiran 2017-09-19
Hii, I am from Dadra and Nagar Haveli, plz let me know What is gonorrhoea ?
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0 # Dr. Pooja 2017-09-20
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Dadra and Nagar Haveli, find list of Gynecologist in Dadra and Nagar Haveli
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0 # Vaibhav Older than three months
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in Cochin ?
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0 # Dr. Naresh Older than three months
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in Cochin
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0 # Tushar Older than three months
Hii, I am from Badaun, Please tell that can moisture be responsible for infections ?
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0 # Dr. Pooja Older than three months
Hello, good to see that you are from Badaun, yes,that is why u must keep your genital organs clean and dry because moisture can favour infections.
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0 # Aarush Older than three months
Hello, plz tell me what are venereal diseases, can you plz suggest some good gynecologist in Guwahati ?
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0 # Dr. Pooja Older than three months
veneral diseases are those which can be spread through sexual contact, The spreading agents can bacteria ,viruses etc, The examples are syphilis and gonorrhoea can be can spread by sexual contact, you can also find list of Gynecologist in Guwahati.
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