Frequently Asked Questions (FAQs) on erythropoiesis-or-blood-formation | HospitalKhoj

ERYTHROPOIESIS OR BLOOD FORMATION

ERYTHROPOIESIS OR BLOOD FORMATION

Ques. 1        Describe the stages of Erythropoiesis or how erythropiesis occurs? What factors are responsible for Erythropoleses? [discuss the role of anoxia (hypoxia) & vitamins in erythropoiesis].

Ans.             In the early embryo – Red – call formation takes place in the area vasculosa of the yolk-sac. This consists of a syncytium of branched cells. The angioblasts from plexuses. Fluid droplets appear gradually in these syncytial masses & run together. Thus a part is hollowed out to from network of capillaries at abut the 3rd week of intra-uterine life. The remains of syncytial masses persist as endothelial lining which in places divides to form masses of round cells. These cells are calls Megaloblasts. They start acquiring Hb and are know as Erythroblasts.

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They become free in blood-stream, and finally about the mid-foetal life lose their nuclei to become non-nucleated discs.

Mid-foetal life to about 1 month before birth – As foetal development proceeds, the endothelial lining of vascular channels of the liver and the spleen divides and forms nucleated red cells. In acute haemopoietic crisis they may resume this function even after birth.

After birth – Red-cell formation takes place in red bone marrow. Its vascular bed is a meshwork of small blood sinuses called sinusoids lined by thin endothelium. A large number of these intercommunicating sinusoids are normally collapsed & quite impermeable to blood. Others are widely dilated, but owing to the vessels which lead to from them being contricted, they are isolated from the general circulation. Regions of low oxygen tension are thus produced, which serve as stimuli to formation of red cells. It is these collapsed inter-sinusoidal capillaries of ‘Sabin’ where erythropoiesis occurs after birth. Plasma filters in from adjacent capillaries & sweeps into circulation the newly formed red cells. The collapsed capillaries open up as soon as normoblasts have lost their nuclei.

  1. In the final stage of maturation the nuclei break up into fragments and disappear, leaving young red cellsThe cells are larger in number and the diameter of a cell varies from 5.5 to 8.8 (mean diameter is 7.3). Shape may be circular or bi-concave, when it is viewed from side, it looks like a dumb-bell. Average thickness is 2.2. Average surface is 120 sq.

    Functions of R.B.C. : (i) It maintains ionic balance and acid – base balance. (ii) It help to maintain viscosity of blood. (iii) Various pigments are derived from haemoglobin after the disintegration of the red cells, e.g. bilirubin, biliverdin etc. (iv) It helps respiration by carrying O2 and CO2.

    Development of R.B.C. : Development process of R.B.C. is Reticulo-Endothelial Cells – Haemocytoblast – Pro-erythroblast – Early normoblast – Late normoblast – Reticulocyte – Erythrocyte.

    Normal total count of R.B.C. : (i) In infants: 6 to 7 million/cu. mm. (ii) In adult male : 5 to 6 million / cu.mm. (iii) In adult female : 4 to 5 million / cu. mm. (iv) In foetus : 7 to 8 million / cu.mm.

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Comments

0 # Harikiran Older than three months
Hello I am from Hailakandi, My neighbour has been feeling redness and burning in urethral organs, can it be a disease, should she visit gynec?
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0 # Dr. Pooja Older than three months
It can be a simple infection also and a disease also, If after the examination, the presence of gram negative bacteria is seen ,gonorrhoea infection can be thought of, she should visit good women's specialist- find list of Gynecologist in Hailakandi
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0 # Jayesh Older than three months
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in Nagpur ?
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0 # Dr. Pooja Older than three months
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in Nagpur
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0 # Vaibhav Older than three months
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Basti ?
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0 # Dr. Pooja Older than three months
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Basti
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0 # Aarav Older than three months
Hello, I am from Theni, PLz suggest some biochemic remedies for gonorrhoea .
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0 # Dr. Pooja Older than three months
Kali Mur, Natrum Mur, Natrum Sulph, and silicea are few important biochemic emedies in homoeopathy which can be used safely in this case, you can also take advise from gynecologist given here-Gynecologist in Theni.
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0 # Aayush Older than three months
Hii, plz tell me,Which tests can confirm syphilis in primary stage, also suggest name of good maternity hospitals in Latur ?
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0 # Dr. Naresh Older than three months
During the primary stage,DG illumination tests are very helpful, find good maternity hospitals-Latur Medical Foundation Private Limited.
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0 # Aarush Older than three months
Can gonorrhoea be caused by the infected towels, also provide the list of good gynecologist in Gurdaspur?
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0 # Dr. Naresh Older than three months
Gonorrhoea can be transmitted by the infected towels, handkerchiefs of the infected person, But most cases are due to sexual contacts, find here list of good Gynecologist in Gurdaspur.
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0 # Tushar Older than three months
Hii, I am from Baleshwar, plz let me know What is gonorrhoea ?
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0 # Dr. Naresh Older than three months
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Baleshwar, find list of Gynecologist in Baleshwar
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0 # Lakshay Older than three months
Hello, plz let me know Can gonorrhoea be transmitted to small children, should I consult with good maternity doctor in Mandsaur
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0 # Dr. Naresh Older than three months
yes,this can be transmitted by infected mothers to children, In this case it is called as ophthalmia neonatorum, find list of good doctor-.Obstetrician in Mandsaur
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0 # Rohan Older than three months
Hii, I am from Auraiya, plz let me know What is gonorrhoea ?
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0 # Dr. Naresh Older than three months
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Auraiya, find list of Gynecologist in Auraiya
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0 # Lakshay Older than three months
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in Durg ?
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0 # Dr. Naresh Older than three months
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in Durg
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