Facts about the Mitochondrial myopathies, one of the degenerative diseases
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Facts about the Mitochondrial myopathies, one of the degenerative diseases

Facts about the Mitochondrial myopathies, one of the degenerative diseases

Mitochondrial Myopathy is one of the neuromuscular diseases. This type of body condition arises when a person’s intracellular structures get damaged. This leads to muscular contractions that are weak, causing hindrances in producing energy. No specific treatment is available for this disease.

What you must know about Mitochondrial Myopathies? ---a brief knowledge of the disease

Mitochondrial Myopathies is a group of diseases, affecting neuro-muscles. The disease causes damage to the mitochondria, which is the structured source of energy for our cells. Nerve cells in our muscles as well our brain need a considerable amount of energy. So to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

Diagnosis & prognosis of Mitochondrial Myopathy

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death.

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Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Symptoms of the disease

A patient with this disease will experience weakness or fatigues in their muscles. These patients may also have exercise intolerance. Cramping of muscles, although rare, but not impossible. Symptoms like muscle weakness, headache, rhythm disturbances or heart failure / breathlessness, movement disorder, dementia, seizures & vomiting, limited mobility of eyes, droopy eyelids, blindness, deafness and some type of strokes are associated with this problem.

What factors are responsible for this body disorder?

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrialSo to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death. Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrial. The mediation of ROS concentration is done by mitochondrial antioxidants such as glutathione peroxidase and manganese superoxide dismutase (SOD2). The central feature of every type of neurodegenerative disorder is over production of ROS. In this case, in addition to the over production of ROS, mitochondrial also remain involved with mitochondrial fission, calcium homeostasis, PCD, fusion, mitochondrial permeability transition and lipid concentration of the mitochondrial membranes. There is likelihood of neurodegeneration due to mitochondrial disease, at least on some level. As far as neurodegenerative disease pathogenesis is concerned, there is the involvement of a casual role, played by oxidative stress and mitochondrial dysfunction.

The common names related with the disease

Myoclonus epilepsy with ragged-red fibres, Kearns-Sayre syndrome, some types of Strokes and Mitochondrial Encephalo-myopathy with lactic acidosis are the commonly known diseases related to Mitochondrial Myopathies.

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Comments

0 # Aarav Older than three months
Hii, plz tell me,Which tests can confirm syphilis in primary stage, also suggest name of good maternity hospitals in Nanded ?
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0 # Dr. Pooja Older than three months
During the primary stage,DG illumination tests are very helpful, find good maternity hospitals-Toshniwal Chest Hospital Maternity and Nursing Home ; Shrinath Maternity and Child Hospital.
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0 # Aarush Older than three months
Hello, plz tell me what are venereal diseases, can you plz suggest some good gynecologist in Mahendergarh ?
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0 # Dr. Naresh Older than three months
veneral diseases are those which can be spread through sexual contact, The spreading agents can bacteria ,viruses etc, The examples are syphilis and gonorrhoea can be can spread by sexual contact, you can also find list of Gynecologist in Mahendergarh.
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0 # Priyansh Older than three months
Hii can you plz tell me, Which fluids can cause or spread syphilis infection, alos give me the list of good gynec in Gadag?
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0 # Dr. Pooja Older than three months
Infection from semen, blood or lactation milk can occur and cause syphilis, Infection from blood syringes is very common, Infected mothers can transmit it through their milk also, consult with good Gynecologist in Gadag .
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0 # Aayush Older than three months
Hello, plz let me know Can gonorrhoea be transmitted to small children, should I consult with good maternity doctor in Thiruvannamalai
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0 # Dr. Naresh Older than three months
yes,this can be transmitted by infected mothers to children, In this case it is called as ophthalmia neonatorum, find list of good doctor-.Obstetrician in Thiruvannamalai
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0 # Priyansh Older than three months
Hii, I am from Hamirpur, I want to know can cigerrete sharing can lead to syphilis ?
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0 # Dr. Pooja Older than three months
yes,sharing cigerette,drinking cups,common spoons etc can also lead to syphilis, Generally whenever the fluid of a person who has syphilis is shared,the infection can occur, you should also consult with good Gynecologist in Hamirpur
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0 # Harikiran Older than three months
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in East Siang ?
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0 # Dr. Naresh Older than three months
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in East Siang
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0 # Vivaan Older than three months
Hello, I am from Kolasib, PLz suggest some biochemic remedies for gonorrhoea .
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0 # Dr. Naresh Older than three months
Kali Mur, Natrum Mur, Natrum Sulph, and silicea are few important biochemic emedies in homoeopathy which can be used safely in this case, you can also take advise from gynecologist given here-Gynecologist in Kolasib.
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0 # Vaibhav Older than three months
Hii can you plz tell me, Which fluids can cause or spread syphilis infection, alos give me the list of good gynec in Shimoga?
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0 # Dr. Pooja Older than three months
Infection from semen, blood or lactation milk can occur and cause syphilis, Infection from blood syringes is very common, Infected mothers can transmit it through their milk also, consult with good Gynecologist in Shimoga .
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0 # Nishith Older than three months
Hii, can you plz tell me,What changes can occur in skin in syphilis patient, also suggest good obstertrician in Sabarkantha ?
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0 # Dr. Naresh Older than three months
Rashes can occur on the skin in the near areas,rashes can be discrete and also symmetrical in nature, Rashes can also be pustular, you can consult with Obstetrician in Sabarkantha.
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0 # Nishith Older than three months
Hello, plz let me know Can gonorrhoea be transmitted to small children, should I consult with good maternity doctor in Kachchh
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0 # Dr. Naresh Older than three months
yes,this can be transmitted by infected mothers to children, In this case it is called as ophthalmia neonatorum, find list of good doctor-.Obstetrician in Kachchh
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