Facts about the Mitochondrial myopathies, one of the degenerative diseases
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Facts about the Mitochondrial myopathies, one of the degenerative diseases

Facts about the Mitochondrial myopathies, one of the degenerative diseases

Mitochondrial Myopathy is one of the neuromuscular diseases. This type of body condition arises when a person’s intracellular structures get damaged. This leads to muscular contractions that are weak, causing hindrances in producing energy. No specific treatment is available for this disease.

What you must know about Mitochondrial Myopathies? ---a brief knowledge of the disease

Mitochondrial Myopathies is a group of diseases, affecting neuro-muscles. The disease causes damage to the mitochondria, which is the structured source of energy for our cells. Nerve cells in our muscles as well our brain need a considerable amount of energy. So to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

Diagnosis & prognosis of Mitochondrial Myopathy

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death.

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Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Symptoms of the disease

A patient with this disease will experience weakness or fatigues in their muscles. These patients may also have exercise intolerance. Cramping of muscles, although rare, but not impossible. Symptoms like muscle weakness, headache, rhythm disturbances or heart failure / breathlessness, movement disorder, dementia, seizures & vomiting, limited mobility of eyes, droopy eyelids, blindness, deafness and some type of strokes are associated with this problem.

What factors are responsible for this body disorder?

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrialSo to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death. Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrial. The mediation of ROS concentration is done by mitochondrial antioxidants such as glutathione peroxidase and manganese superoxide dismutase (SOD2). The central feature of every type of neurodegenerative disorder is over production of ROS. In this case, in addition to the over production of ROS, mitochondrial also remain involved with mitochondrial fission, calcium homeostasis, PCD, fusion, mitochondrial permeability transition and lipid concentration of the mitochondrial membranes. There is likelihood of neurodegeneration due to mitochondrial disease, at least on some level. As far as neurodegenerative disease pathogenesis is concerned, there is the involvement of a casual role, played by oxidative stress and mitochondrial dysfunction.

The common names related with the disease

Myoclonus epilepsy with ragged-red fibres, Kearns-Sayre syndrome, some types of Strokes and Mitochondrial Encephalo-myopathy with lactic acidosis are the commonly known diseases related to Mitochondrial Myopathies.

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Comments

# Aarav 2017-12-09
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# Lakshay 2017-10-28
Hii, I am from Kurung Kumey, plz let me know What is gonorrhoea ?
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# Dr. Pooja 2017-10-29
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Kurung Kumey, find list of Gynecologist in Kurung Kumey
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# Nishith 2017-10-28
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# Dr. Naresh 2017-10-29
Rashes can occur on the skin in the near areas,rashes can be discrete and also symmetrical in nature, Rashes can also be pustular, you can consult with Obstetrician in Jaintia Hills.
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# Aarav 2017-10-14
Hello, plz let me know What is menarche, I want to consult with gynec in Sheikhpura, plz suggest ?
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# Dr. Naresh 2017-10-15
the process of starting of the menstrual cycle in females is called menarche, plz find good Gynecologist in Sheikhpura.
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# Aarav 2017-10-14
Hii, I am from Namsai, I want to know can cigerrete sharing can lead to syphilis ?
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# Dr. Pooja 2017-10-15
yes,sharing cigerette,drinking cups,common spoons etc can also lead to syphilis, Generally whenever the fluid of a person who has syphilis is shared,the infection can occur, you should also consult with good Gynecologist in Namsai
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# Aayush 2017-09-23
Hello, plz let me know Can gonorrhoea be transmitted to small children, should I consult with good maternity doctor in Kolhapur
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# Dr. Pooja 2017-09-24
yes,this can be transmitted by infected mothers to children, In this case it is called as ophthalmia neonatorum, find list of good doctor-.Obstetrician in Kolhapur
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# Aayush 2017-09-23
Hii, can you plz tell me,What changes can occur in skin in syphilis patient, also suggest good obstertrician in Subarnapur ?
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# Dr. Naresh 2017-09-24
Rashes can occur on the skin in the near areas,rashes can be discrete and also symmetrical in nature, Rashes can also be pustular, you can consult with Obstetrician in Subarnapur.
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# Harikiran 2017-09-23
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# Dr. Naresh 2017-09-24
veneral diseases are those which can be spread through sexual contact, The spreading agents can bacteria ,viruses etc, The examples are syphilis and gonorrhoea can be can spread by sexual contact, you can also find list of Gynecologist in Navsari.
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# Lakshay Older than three months
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Keonjhar ?
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# Dr. Naresh 2017-09-10
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Keonjhar
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# Aarush Older than three months
Hello, I am from Bhopal, PLz suggest some biochemic remedies for gonorrhoea .
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# Dr. Naresh Older than three months
Kali Mur, Natrum Mur, Natrum Sulph, and silicea are few important biochemic emedies in homoeopathy which can be used safely in this case, you can also take advise from gynecologist given here-Gynecologist in Bhopal.
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