Facts about the Mitochondrial myopathies, one of the degenerative diseases
  • Home
  • Health Facts
  • Facts about the Mitochondrial myopathies, one of the degenerative diseases

Facts about the Mitochondrial myopathies, one of the degenerative diseases

Facts about the Mitochondrial myopathies, one of the degenerative diseases

Mitochondrial Myopathy is one of the neuromuscular diseases. This type of body condition arises when a person’s intracellular structures get damaged. This leads to muscular contractions that are weak, causing hindrances in producing energy. No specific treatment is available for this disease.

What you must know about Mitochondrial Myopathies? ---a brief knowledge of the disease

Mitochondrial Myopathies is a group of diseases, affecting neuro-muscles. The disease causes damage to the mitochondria, which is the structured source of energy for our cells. Nerve cells in our muscles as well our brain need a considerable amount of energy. So to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

Diagnosis & prognosis of Mitochondrial Myopathy

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death.

You must also Read:
How Physiotherapy is Beneficial for Back Pain
How Swimming Exercises is The Best for Our Health?
Dehydration In Adults - Some Facts To Know
Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Symptoms of the disease

A patient with this disease will experience weakness or fatigues in their muscles. These patients may also have exercise intolerance. Cramping of muscles, although rare, but not impossible. Symptoms like muscle weakness, headache, rhythm disturbances or heart failure / breathlessness, movement disorder, dementia, seizures & vomiting, limited mobility of eyes, droopy eyelids, blindness, deafness and some type of strokes are associated with this problem.

What factors are responsible for this body disorder?

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrialSo to keep supplying energy mitochondria must remain healthy. But, in case of any occurrence of any type of its dysfunction, our cells will not get required amount of energy, resulting to un-repairable damage to our brain functioning and muscular contraction.

The type of the disease determines its prognosis. Generally this disease is progressive and fatal in nature that causes even death. Extensive researches are going on to find some treatment and know about the other aspects of the disease, but this relatively rare disorder has found few. The severity of the form of trouble determines the prognosis of this disorder. Many of the patients suffer this body condition even before they can attain their age of 20.

Most of the cell deaths, attached with the neurodegeneration, take place in the central mitochondrial apoptotic pathway. The activation of caspase-9 is controlled in this pathway. The controlling system regulates the release of Cytochrome C, which gets released from the mitochondrial IMS (intermembrane space). Normally, ROS (Reactive Oxygen Species) are the by-products of respiratory chain activities of mitochondrial. The mediation of ROS concentration is done by mitochondrial antioxidants such as glutathione peroxidase and manganese superoxide dismutase (SOD2). The central feature of every type of neurodegenerative disorder is over production of ROS. In this case, in addition to the over production of ROS, mitochondrial also remain involved with mitochondrial fission, calcium homeostasis, PCD, fusion, mitochondrial permeability transition and lipid concentration of the mitochondrial membranes. There is likelihood of neurodegeneration due to mitochondrial disease, at least on some level. As far as neurodegenerative disease pathogenesis is concerned, there is the involvement of a casual role, played by oxidative stress and mitochondrial dysfunction.

The common names related with the disease

Myoclonus epilepsy with ragged-red fibres, Kearns-Sayre syndrome, some types of Strokes and Mitochondrial Encephalo-myopathy with lactic acidosis are the commonly known diseases related to Mitochondrial Myopathies.

.
Below Articles may be helpful to you:
Be careful about monsoon season's darker sides
Surprising Causes Behind Constipation
Is Sugar Free Natura Healthy and Good for Health?

Ask our Counsellors


Comments

0 # Aayush 2018-10-27
Hi, plz let me know What is the incubation period of Syphilis, also give me the list of good female's specialist in Tinsukia ?
Reply | Reply with quote | Quote
0 # Dr. Naresh 2018-10-28
Hii, The incubation period can be 10 to 90 days, plz find list of Gynecologist in Tinsukia
Reply | Reply with quote | Quote
0 # Aarush 2018-10-20
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Lower Subansiri ?
Reply | Reply with quote | Quote
0 # Dr. Naresh 2018-10-21
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Lower Subansiri
Reply | Reply with quote | Quote
0 # Aarav 2018-10-13
Hello I am from Deoghar, My neighbour has been feeling redness and burning in urethral organs, can it be a disease, should she visit gynec?
Reply | Reply with quote | Quote
0 # Dr. Pooja 2018-10-14
It can be a simple infection also and a disease also, If after the examination, the presence of gram negative bacteria is seen ,gonorrhoea infection can be thought of, she should visit good women's specialist- find list of Gynecologist in Deoghar
Reply | Reply with quote | Quote
0 # Aarav 2018-09-22
Can gonorrhoea be caused by the infected towels, also provide the list of good gynecologist in Panna?
Reply | Reply with quote | Quote
0 # Dr. Pooja 2018-09-23
Gonorrhoea can be transmitted by the infected towels, handkerchiefs of the infected person, But most cases are due to sexual contacts, find here list of good Gynecologist in Panna.
Reply | Reply with quote | Quote
0 # Vaibhav 2018-09-08
Hello I am from Neemuch, My neighbour has been feeling redness and burning in urethral organs, can it be a disease, should she visit gynec?
Reply | Reply with quote | Quote
0 # Dr. Naresh 2018-09-09
It can be a simple infection also and a disease also, If after the examination, the presence of gram negative bacteria is seen ,gonorrhoea infection can be thought of, she should visit good women's specialist- find list of Gynecologist in Neemuch
Reply | Reply with quote | Quote
0 # Priyansh 2018-09-08
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in West Sikkim ?
Reply | Reply with quote | Quote
0 # Dr. Pooja 2018-09-09
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in West Sikkim
Reply | Reply with quote | Quote
0 # Aayush 2018-08-25
Hii, I am from Sawai Madhopur, can you plz tell me What is the mode of infection in syphilis ?
Reply | Reply with quote | Quote
0 # Dr. Naresh 2018-08-26
90 percent cases in syphilis are transmitted through unsafe sexual contacts, Mothers can also pass infection through breast milk, you can also consult with good Gynecologist in Sawai Madhopur .
Reply | Reply with quote | Quote
0 # Jayesh 2018-08-16
Hii, I am from Vijayawada, plz let me know What is gonorrhoea ?
Reply | Reply with quote | Quote
0 # Dr. Pooja 2018-08-17
Hello, Gonorrhoea is a sexually transmitted disease caused by the Neisseria gonorrhoea,This disease is caused in the genitourinary tracts, for more details plz visit good gynec in Vijayawada, find list of Gynecologist in Vijayawada
Reply | Reply with quote | Quote
0 # Tushar Older than three months
Hii, I am from Nanded, Please tell that can moisture be responsible for infections ?
Reply | Reply with quote | Quote
0 # Dr. Naresh Older than three months
Hello, good to see that you are from Nanded, yes,that is why u must keep your genital organs clean and dry because moisture can favour infections.
Reply | Reply with quote | Quote
0 # Vaibhav Older than three months
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Sangli ?
Reply | Reply with quote | Quote
0 # Dr. Naresh Older than three months
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Sangli
Reply | Reply with quote | Quote