Newly Discovered Gene May Increase Inflammation in Asthmatic Patients
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Newly Discovered Gene May Increase Inflammation in Asthmatic Patients

Australian scientist have revealed in a breakthrough discovery that, PAG1, a gene, is likely to boost inflammation in people who suffer from conditions like asthma.

Dr. Manuel Ferreira from QIMR Berghofer’s Asthma Genetics laboratory stated that in massive study in genetics, they have discovered an unknown variant of gene which can increase the risk of asthma and similar allergies by approximately twenty percent. As it wasn’t certainly obvious which gene will be impacted by that variant, series of molecular experiments were designed for the identification of that particular gene.

To this Dr. Ferreira further added that they are now aware that as the risk variant was identified at a significant distance from the gene PAG1, the risk variant can easily reach that gene via DNA looping. DNA looping is the name of the entire process. It is also seems to increase PAG1 expression in people suffering from Asthma.

The recent study seems to contradict many of the previous studies which were related to the functioning of PAG1 gene in our immune system and serves for a potential new treatment target. He also said that in many of the studies on animal models and cells of human no stimulation was noticed in the immune system.

Dr. Ferreira also believes that the functioning of PAG1 can also be dependent on the context of the challenges in immune in conditions like allergen or virus it can have a pro-inflammatory response. A variant identified by him in the year 2016 that was responsible for a clinical trial underway in Brisbane, which is examining if a drug used to cure rheumatoid arthritis can be helpful in curing asthma.

Thirty to fifty percent of people suffer from some kind of allergy, which is mostly common in their early years, stated Dr.

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Australian scientist have revealed in a breakthrough discovery that, PAG1, a gene, is likely to boost inflammation in people who suffer from conditions like asthma.

Thirty to fifty percent of people suffer from some kind of allergy, which is mostly common in their early years, stated Dr. Ferreira.

 

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Comments

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0 # Dr. Pooja Older than three months
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0 # Dr. Naresh Older than three months
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0 # Dr. Pooja Older than three months
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0 # Dr. Pooja Older than three months
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0 # Dr. Naresh Older than three months
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0 # Rohan Older than three months
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0 # Dr. Pooja Older than three months
Hello, good to see that you are from Mannar, yes,that is why u must keep your genital organs clean and dry because moisture can favour infections.
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0 # Aarav Older than three months
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0 # Dr. Naresh Older than three months
Hello, good to see that you are from Kolhapuri, yes,that is why u must keep your genital organs clean and dry because moisture can favour infections.
Reply | Reply with quote | Quote
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Hello I am from Jamnagar, My neighbour has been feeling redness and burning in urethral organs, can it be a disease, should she visit gynec?
Reply | Reply with quote | Quote
0 # Dr. Pooja Older than three months
It can be a simple infection also and a disease also, If after the examination, the presence of gram negative bacteria is seen ,gonorrhoea infection can be thought of, she should visit good women's specialist- find list of Gynecologist in Jamnagar
Reply | Reply with quote | Quote
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0 # Dr. Naresh Older than three months
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