Better you have a deeper knowledge about Membrane Damage
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Better you have a deeper knowledge about Membrane Damage

Better you have a deeper knowledge about Membrane Damage

The cause of this disease is damage to the organelles’ membranes by the oligomeric or monomeric or proteins. By inducing membrane curvature, membranes can be damaged by Alpha-synuclein. Due to this, an extensive vesiculation and tabulation are observed, as these proteins get incubated under the system of artificial phospholipid vesicles.

Cell injury & the Mechanisms of Membrane damage

Increased cytosolic Ca2+ and Decreased O2 are the typically found ischemia. However, it can get attached with other types of cell injury. ROS (Reactive oxygen species) are the commonly produced species due to the ischemic tissues’ reperfusions. This is also one of the causes for membrane damage.

Extension of membrane damage

In case selective membrane permeability is lost earlier than normal, it may ultimately lead to overt membrane damage, which is the consistent feature in most of the cases of cell injury. Due to the membrane damage, the plasma membrane, the mitochondria and other cellular membranes get affected.

In the context of ischemic cells, the causes of membrane defects may be due to the actions of series of events. This results to the depletion of ATP and activation of phospholipases due to calcium modulation.

Damage of plasma membrane is also prone to be directly damaged by certain viral proteins, bacterial toxins, different types of chemical & physical agents and lytic complement components. Many biochemical mechanisms may lead to damage of membrane.

Causes of Mitochondrial dysfunction

The decrease in the phospholipid synthesis is due to the defective mitochondrial function, affecting all cellular membranes, not even excluding the mitochondria themselves.

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In furtherance to this, in case ATP depletes, cytosolic calcium increases on the other hand, resulting into activation of phospholipases and rise in Ca+2 into the mitochondria that results into breaking down of phospholipids. The ultimate results are accumulation of free fatty acids and phospholipids’ depletion from the mitochondria and also from other cellular membranes. Due to these changes, permeability defects are found in mitochondria. To exemplify it, because of transition of mitochondrial permeability, occurrences of loss of membrane phospholipids and progressions of cell injury are the fallouts.

The few other factors of cell injury occur if membrane phospholipids content decreases because of its likelihood of degradation. The reason is the activation of endogenous phospholipases due to upsurge in the cytosolic calcium’s level. The loss of Phospholipid is related to the reduction in the de novo synthesis of phospholipids or the decrease in the ATP-based reacylation.

The after-effects of all the above

Damage in cytoplasmic membrane is the major after-effect of these situations. Influx of ions & fluids and loss of osmotic balance, loss of coenzymes, proteins, enzymes and ribonucleic acids are the ultimate results of the damage to the Plasma membrane. There are also possibilities that metabolites, which are very crucial for the ATP reconstruction, will be leaked by cells. This will further deplete the net intracellular high-value phosphates.

If there is any injury in the lysosomal membranes, there will be likelihood of enzyme-leakages. Lysosomes Lysosomes are constituent of glucosidases, cathepsins, proteases, phosphatases, RNases and DNases.

 
By inducing membrane curvature, membranes can be damaged by Alpha-synuclein. Due to this, an extensive vesiculation and tabulation are observed, as these proteins get incubated under the system of artificial phospholipid vesicles.

The decrease in the phospholipid synthesis is due to the defective mitochondrial function, affecting all cellular membranes, not even excluding the mitochondria themselves. In furtherance to this, in case ATP depletes, cytosolic calcium increases on the other hand, resulting into activation of phospholipases and rise in Ca+2 into the mitochondria that results into breaking down of phospholipids. The ultimate results are accumulation of free fatty acids and phospholipids’ depletion from the mitochondria and also from other cellular membranes. Due to these changes, permeability defects are found in mitochondria. To exemplify it, because of transition of mitochondrial permeability, occurrences of loss of membrane phospholipids and progressions of cell injury are the fallouts.

 
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Comments

0 # Jayesh 2017-10-17
Hello, I am from Moga, PLz suggest some biochemic remedies for gonorrhoea .
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0 # Dr. Naresh 2017-10-18
Kali Mur, Natrum Mur, Natrum Sulph, and silicea are few important biochemic emedies in homoeopathy which can be used safely in this case, you can also take advise from gynecologist given here-Gynecologist in Moga.
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0 # Vivaan 2017-09-18
Hii, I am from Faizabad, I want to know can cigerrete sharing can lead to syphilis ?
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0 # Dr. Pooja 2017-09-19
yes,sharing cigerette,drinking cups,common spoons etc can also lead to syphilis, Generally whenever the fluid of a person who has syphilis is shared,the infection can occur, you should also consult with good Gynecologist in Faizabad
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0 # Lakshay Older than three months
Hello, plz let me know Can gonorrhoea be transmitted to small children, should I consult with good maternity doctor in Lohit
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0 # Dr. Pooja Older than three months
yes,this can be transmitted by infected mothers to children, In this case it is called as ophthalmia neonatorum, find list of good doctor-.Obstetrician in Lohit
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0 # Priyansh Older than three months
Hii can you plz tell me, Which fluids can cause or spread syphilis infection, alos give me the list of good gynec in Andaman?
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0 # Dr. Pooja Older than three months
Infection from semen, blood or lactation milk can occur and cause syphilis, Infection from blood syringes is very common, Infected mothers can transmit it through their milk also, consult with good Gynecologist in Andaman .
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0 # Vivaan Older than three months
My friend has been diagnosed with gonorrhoea, Please tell which tests will be advisable, also suggest gynec in Tonk ?
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0 # Dr. Naresh Older than three months
VDRL tests should be done every month for 3 consecutive months for detecting syphilis as well as other sexually transmitted diseases,These tests should be conducted at proper times, find good Gynecologist in Tonk
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